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Sedating strains are a different category of kratom as they are deficient in the more stimulating alkaloids, like mitragynine.

Both physical and psychological dependence can be treated with therapy.

Intensive care unit patients who receive higher doses over longer periods, typically via IV drip, are more likely to experience such side effects.

Sedatives — most commonly alcohol — have been reported for their use as date rape drugs (also called a Mickey) and being administered to unsuspecting patrons in bars or guests at parties to reduce the intended victims' defenses. Statistical overviews suggest that the use of sedative-spiked drinks for robbing people is actually much more common than their use for rape., as the loss of inhibitions from the drug may increase their confidence to commit the offence, and the amnesia produced by the drug makes it difficult for police to interrogate them if they are caught.

Many sedatives can be misused, but barbiturates and benzodiazepines are responsible for most of the problems with sedative use due to their widespread recreational or non-medical use.

People who have difficulty dealing with stress, anxiety or sleeplessness may overuse or become dependent on sedatives.

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Sedatives can be misused to produce an overly-calming effect (alcohol being the classic and most common sedating drug).

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