Elucidating altered transcriptional programs

Elucidating altered transcriptional programs

He has served as President of the American Society for Cell Biology, chaired the NAS committees that established Guidelines for Human Embryonic Stem Cell Research and currently the NAS/NAM Committee on Human Genome Editing. × University of California, Berkeley, Howard Hughes Medical Institute Dr.Kuriyan earned his Ph D in 1986 from the Massachusetts Institute of Technology.Under his leadership, fourteen new medicines have come to market including Baraclude (Hepatitis B), Orencia (Rheumatoid Arthritis), Sprycel (Leukemia), Eliquis (Anticoagulant), and the first checkpoint inhibitor, Yervoy (Melanoma). Sigal was named the best R&D chief in the pharmaceutical industry by Scrip Intelligence. Prior to medical school he studied engineering at Purdue University, where he received a B. His work in mice is currently focused on limbic circuits, including the amygdala and hypothalamus, and their role in aggression.Anderson has trained over 50 postdoctoral fellows and Ph. students in his 30 years on the faculty at Caltech.This cookie stores just a session ID; no other information is captured.Accepting the NEJM cookie is necessary to use the website.Evans is a Howard Hughes Medical Institute Investigator and the recipient of multiple awards, including the Albert Lasker Award (2004) and the Wolf Prize (2012), and a Member of the National Academy of Sciences and the Institute of Medicine.

Molecular understanding of cell-ECM interactions is also being exploited in tissue engineering and regenerative medicine. Hynes' awards include the Gairdner International Award, a Guggenheim Fellowship, the Pasarow Award and the E. Wilson medal of the American Society for Cell Biology, in recognition of his research on extracellular matrix, integrins and cell adhesion.

His muscle metabolism studies led to the discovery of exercise mimetics, which promote the benefits of fitness without training.

Exercise mimetics will help battle the obesity epidemic, diabetes, heart disease, hypertension and cancer.

Ludwig Professor for Cancer Research at the Koch Institute and Department of Biology at MIT, Investigator of the Howard Hughes Medical Institute and Senior Associate Member of the Broad Institute.

He was formerly Associate Head and then Head of the Biology department and was Director of the MIT Center for Cancer Research (now the Koch Institute) for 10 years.

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These discoveries established the extracellular matrix (ECM), previously viewed largely as a structural entity, as having a vital role in controlling cell adhesion, morphology and migration. Hynes also made major contributions to the discovery and first cloning of integrins, a family of receptors that bind fibronectin and other cell adhesion molecules and form transmembrane links to the cytoskeleton.

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